Their key advantage rely on the measurement of phenotypes independently of molecular target assumptions. We developed a whole pipeline of assays to allow highthroughput with high value assays for hit identification, lead optimization as well as resistance evaluation. Active compounds in organism-based assays have not only to act on their targets but also have to cross biological barriers, resist metabolization and reach one or more targets causing an effect at the whole – organism level.

Electrophysiology assays represent our second main domain of activity. The Xenopus oocyte expression system allows to express functional ion-channels in the membrane of individual cells and measure their physiological function.

We measure the effect of compounds on ligand-gated ion-channels, voltage-gated ion-channels, GPCRs and transporters. Oocytes are injected with cDNA or cRNA encoding the receptor of interest using an automated injection platform (Roboinject). The effect of compounds on the heterologously expressed channels are recorded using an automated two electrodes voltage-clamp automate (HiClamp, Multichannelsystem).

Research projects often necessitate the creation of tailored protocols to test specific hypotheses. Our team is eager to take on projects that involve research and development. To ensure that we can address any new challenges that may arise, we make use of our extensive expertise in Animal Health and the development of new protocols to cater to your specific needs. We are committed to providing you with the best possible solutions to your research projects.